THE SYNTHESIS OF NOVEL SUBSTITUTED 2,5-DIOXO-1,2,3,4,5,6,7,8-OCTAHYDROQUINOLINES WITHOUT SOLVENT UNDER MICROWAVE IRRADIATION
- 1 January 2001
- journal article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 31 (17) , 2657-2661
- https://doi.org/10.1081/scc-100105393
Abstract
A convenient synthetic method for substituted 2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinolines is described. Heating Meldrum's acid, dimedone, ammonium acetate and different aromatic aldehydes without a solvent in a microwave irradiation for 2–5 minutes affords 4 in 72–86% yield. The structure of these compounds has been thoroughly studied by x-ray crystallographic analysis.Keywords
This publication has 9 references indexed in Scilit:
- A joint experimental and theoretical structural study of novel substituted 2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinolinesTetrahedron, 1999
- An Efficient One-Pot Synthesis of Nitriles from Carboxylic Acids Without Solvent Under Microwave IrradiationSynthetic Communications, 1996
- Microwave assisted organic reactionsTetrahedron, 1995
- Developments in Microwave-Assisted Organic ChemistryAustralian Journal of Chemistry, 1995
- 1,4‐Dihydropyridines—a basis for developing new drugsMedicinal Research Reviews, 1989
- The use of microwave ovens for rapid organic synthesisTetrahedron Letters, 1986
- The agonist effect of dihydropyridines on Ca channelsNature, 1984
- New developments in calcium ion channel antagonistsJournal of Medicinal Chemistry, 1983
- Novel dihydropyridines with positive inotropic action through activation of Ca2+ channelsNature, 1983