Immunoglobulin heavy-chain class switching in a pre-B cell line is accompanied by DNA rearrangement
- 1 November 1983
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 306 (5940) , 243-246
- https://doi.org/10.1038/306243a0
Abstract
Switching of an Abelson virus-transformed mouse lymphoid cell line from Ig .mu. to .gamma.2b H chain synthesis in vitro is accompanied by loss of DNA sequences between the JH [H chain, J region] and C.gamma.2b [constant region of IgG2b] gene segments, and thus cannot be explained by differential RNA processing. The L-chain loci of both .mu.- and .gamma.2b-producing cell clones are in the embryonic configuration, which indicates that class switching can occur in pre-B cells.This publication has 32 references indexed in Scilit:
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