A factor in the increased risk of colorectal cancer due to ingestion of animal fat is inhibition of colon epithelial cell glutathione S-transferase, an enzyme that detoxifies mutagens

This publication has 24 references indexed in Scilit:

• Biotransformation enzymes in human intestine: critical low levels in the colon?
  Gut, 1991
• A genetic model for colorectal tumorigenesis
  Cell, 1990
• Effect of high fat consumption on cell proliferation activity of colorectal mucosa and on soluble faecal bile acids.
  Gut, 1988
• Inhibition of human glutathione S-transferases by bile acids
  Toxicology and Applied Pharmacology, 1988
• Glutathione Transferases—Structure and Catalytic Activit
  Critical Reviews in Biochemistry, 1988
• Proliferative activity of rectal mucosa and soluble fecal bile acids in patients with normal colons and in patients with colonic polyps or cancer
  Cancer Letters, 1988
• Genotoxicity of two fecal steroids in murine colonic epithelium assessed by the sister chromatid exchange technique
  Mutagenesis, 1987
• Dietary Carcinogens and Anticarcinogens
  Science, 1983
• Molecular and catalytic properties of glutathione transferase .mu. from human liver: an enzyme efficiently conjugating epoxides
  Biochemistry, 1983
• Effects of lactulose and other laxatives on ileal and colonic pH as measured by a radiotelemetry device
  Gut, 1974