SYNTHESIS OF γ-GLUTAMYLPHOSPHONODIDEPEPTIDES

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Abstract
γ-Glutamylphosphonodidepsipeptides 3a-f were obtained by condensation of α-t-butyl or α-benzyl ester of optically active N-benzyloxycarbonyl-glutamic acid with di-p-nitrobenzyl 1-hydroxymethanephosphonate, (+) dibenzyl 1-hydroxy-2-methylpropanephosphonate and (-) dibenzyl 1-hydroxy-3 methylbutanephosphonate. Dicyclohexylcarbodiimide in the presence of 4-(N,N-dimethylamino)- pyridine and 1-hydroxybenzotriazole in methylene chloride was used as a condensing agent for compounds 3a-c. Compounds 3d-f were obtained by means of the dicyclohexylcarbodiimide method in the presence of 4-(N, N-dimethylamino)pyridine in carbon tetrachloride. Protecting groups were removed by conventional methods.