Observations on the Different Calcium Metabolic Patterns in Sarcoidosis

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Abstract
Combined Ca balance and 47Ca turnover studies in sarcoidosis (4 patients) and vitamin D intoxication (1 patient) disclosed 3 different patterns of Ca metabolism. One patient with sarcoidosis had a normal metabolism of Ca, and 2 patients presented the usual pattern of intestinal hyperabsorption, hypercalcemia and hypercalciuria. The 4th patient with sarcoidosis and the patient with vitamin D intoxication, both studied during spontaneous remissions, showed hypercalcemia despite normal intestinal absorption of Ca, enlarged exchangeable Ca pool, accelerated accretion and resorption rates, hypercalciuria and a distinctly negative Ca balance. This pattern of remission seems to represent a mobilization of extraosseous or metastatic calcifications, rather than a resorption of bone Ca.

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