Metabolism of Carbon 14 Methyl-Labeled Sodium Acetate Following Thermal Trauma in the Rat

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Abstract
Observations on the metabolism of C14 methyl-labeled sodium acetate have been obtained in 14 control and 11 burned rats. The C14 acetate was given intraperitoneally 3 days after ether anesthesia (control) or after anesthesia and thermal trauma. The losses of C14 in expired air and urine were measured in both groups. The data suggest that tissue protein synthesis from acetate is proceeding in the burned rats and at rates which are almost certainly not slower than in normal rats. This would suggest that generalized antianabolism is not the basis for the increased urinary nitrogen excretion after burns.