Syntheses with stable isotopes: Thymine‐2,6‐13C2
- 1 January 1979
- journal article
- research article
- Published by Wiley in Journal of Labelled Compounds and Radiopharmaceuticals
- Vol. 16 (2) , 315-320
- https://doi.org/10.1002/jlcr.2580160211
Abstract
A three‐step synthesis of thymlne‐2,6‐13C2 from urea‐13C, sodium cyanide‐13C, and α‐bromopropionic acid is described. The last reaction involves hydrogenation of α‐cyano‐13C‐propionylurea‐13C in aqueous acetic acid and produces thymine‐2,6‐13C2 in 50–60% yield. The mechanism of this reaction is discussed.Keywords
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