Phosphatidylinositol 3-Kinase Is Required for Insulin-Like Growth Factor-I–Induced Vascular Smooth Muscle Cell Proliferation and Migration
- 7 January 2000
- journal article
- other
- Published by Wolters Kluwer Health in Circulation Research
- Vol. 86 (1) , 15-23
- https://doi.org/10.1161/01.res.86.1.15
Abstract
—Insulin-like growth factor–I (IGF-I) plays an important role in regulating vascular smooth muscle cell (VSMC) proliferation and directed migration. The mitogenic and chemotactic actions of...Keywords
This publication has 34 references indexed in Scilit:
- A Cell's Sense of DirectionScience, 1999
- Platelet-Derived Growth Factor-BB, Insulin-like Growth Factor-I, and Phorbol Ester Activate Different Signaling Pathways for Stimulation of Vascular Smooth Muscle Cell MigrationExperimental Cell Research, 1998
- Mitogenic Signaling of Insulin-like Growth Factor I in MCF-7 Human Breast Cancer Cells Requires Phosphatidylinositol 3-Kinase and Is Independent of Mitogen-activated Protein KinaseJournal of Biological Chemistry, 1997
- Angiotensin II inhibits insulin signaling in aortic smooth muscle cells at multiple levels. A potential role for serine phosphorylation in insulin/angiotensin II crosstalk.Journal of Clinical Investigation, 1997
- Targeted overexpression of IGF-I evokes distinct patterns of organ remodeling in smooth muscle cell tissue beds of transgenic mice.Journal of Clinical Investigation, 1997
- Phosphatidylinositol 3-Kinase-independent Signal Transduction Pathway for Platelet-derived Growth Factor-induced ChemotaxisPublished by Elsevier ,1996
- Intracellular signaling pathways required for rat vascular smooth muscle cell migration. Interactions between basic fibroblast growth factor and platelet-derived growth factor.Journal of Clinical Investigation, 1995
- The chemotactic response to PDGF-BB: evidence of a role for Ras.The Journal of cell biology, 1995
- The pathogenesis of atherosclerosis: a perspective for the 1990sNature, 1993
- The small GTP-binding protein rac regulates growth factor-induced membrane rufflingCell, 1992