Tcf-3 expression and β -catenin mediated transcriptional activation in aggressive fibromatosis (desmoid tumour)
Open Access
- 3 July 2001
- journal article
- Published by Springer Nature in British Journal of Cancer
- Vol. 85 (1) , 98-101
- https://doi.org/10.1054/bjoc.2001.1857
Abstract
Aggressive fibromatosis harbours mutations resulting in β-catenin protein stabilization. Primary cell cultures demonstrate constitutive tcf activation in aggressive fibromatosis. Expression and co-immunoprecipitation studies suggest that β-catenin binds and activates tcf-3 in this tumour. This is the first demonstration of tcf-3 activation by β-catenin stabilization in a human neoplastic process. © 2001 Cancer Research Campaign http://www.bjcancer.comKeywords
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