Gardner's syndrome with duodenal adenomas, gastric adenomyoma and thyroid papillary—Follicular adenocarcinoma

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Abstract
A case of a woman with Gardner''s syndrome, originally manifested by multiple adenomatous polyps of the colon, is presented. She underwent subtotal colectomy at 14 yr of age. Over the next 15 yr she had a composite odontoma, an impacted supernumerary tooth, 2 epidermal inclusion cysts, multicentric papillary-follicular adenocarcinoma of the thyroid, 2 tubulovillous adenomas of the duodenum in which argyrophilic cells were a prominent feature and an adenomyoma of the gastric antrum. The presence of all of these lesions in 1 patient expands the spectrum of lesions seen with Gardner''s syndrome and supports the concept of a generalized abnormality of growth regulation as the cause of the syndrome.