Evolution of Therapy for Cystic Fibrosis

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Abstract
Thirty years ago, a treatment program for patients with cystic fibrosis was laid out that emphasized combating pulmonary infection, improving bronchial drainage, and attending to nutrition1. This symptomatic approach, devised with no specific knowledge of the basic molecular defect, has served patients well. The median survival age of patients enrolled in this program soared into the third decade, and the quality of life improved dramatically. These three principles of treatment remain the underpinnings of conventional therapy for cystic fibrosis.In this issue of the Journal, Fuchs and coworkers report an approach to improving bronchial drainage that is a product . . .