BETA-ADRE NERGIC BLOCKADE WITH PRONETHALOL DURING ANAESTHESIA

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Abstract
Pronethalol (Alderlin), a derivative of isoprenaline, has proved consistently effective in suppressing the ventricular arrhythmias commonly associated with cyclopropane anaesthesia and occasionally with light halothane anaesthesia. The dose range in adults is 10 to 15 mg intravenously (approximately 0.2 mg/kg). The drug was observed to have no direct effect on the blood pressure or on the periodicity of the sinus and the atrioventricular nodes. It did not alter the conduction time of the pulse wave from the heart to the periphery, as judged by a new system of measurement. There is every indication that pronethalol may be useful in antagonizing the cardiac disturbances caused by the administration of adrenaline to anaesthetized patients.