Effect of Dibutyryl-3′,5′-AMP, Theophylline and Norepinephrine on Lipolytic Action of Growth Hormone and Glucocorticoid in White Fat Cells

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Abstract
The lipolytic action of GH and glucocorticoid on white fat cells was affected by catecholamines and theophylline. GH and glucocorticoid produced a 5- to 10-fold increase in the sensitivity of fat cells to norepinephrine or theophylline without affecting the maximal response. Di-butyryl-3[image],5[image]-AMP also stimulated fat cell lipolysis but GH and glucocorticoid actually inhibited its lipolytic action. The ability of GH and glucocorticoid to increase the sensitivity of fat cells to theophylline was abolished by cycloheximide, an inhibitor of protein synthesis. GH stimulated the synthesis of a protein involved in the formation but not in the action of 3[image],5[image]-AMP.