CARDIAC ALLOGRAFT SURVIVAL IN RHESUS PRIMATES TREATED WITH COMBINED TOTAL LYMPHOID IRRADIATION AND RABBIT ANTITHYMOCYTE GLOBULIN
- 1 October 1979
- journal article
- research article
- Published by Wolters Kluwer Health in Transplantation
- Vol. 28 (4) , 347-350
- https://doi.org/10.1097/00007890-197910000-00017
Abstract
Eighteen abdominal heterotopic cardiac allografts were performed in outbred rhesus primates. For immunosuppression seven animals received six 100-rad/day total lymphoid irradiation (TLI) doses the week preceding transplant and three 3-mg/kg i.m. rabbit antithymocyte globulin (RATG) doses on postoperative days —1, 0, and +1; five animals were given this RATG dose but no irradiation; three were given TLI alone; and three were given no immunosuppressive therapy. Circulating T lymphocyte counts were monitored in all animals (rosettes). Graft survival in the combined TLI-RATG therapy group (169 ±15 days) was significantly greater than in untreated (11 ± 1 days), RATG alone (22 ± 12 days), or TLI alone (38 ± 6 days) treated animals (P < 0.001, 0.0001, and 0.001, respectively). The animals receiving combined TLI-RATG therapy also achieved significantly greater and more prolonged T lymphopenia than that obtained in the other three groups. Six of seven cardiac allografts placed in animals receiving TLI-RATG therapy were re moved electively before cessation of electrical activity; however, in four of these rejection pathology was noted. Thus, it seems that combined TLI-RATG therapy may be of benefit in the management of transplant recipients, but its use will probably not abolish these patients' requirements for immunosuppressive maintenance measures.This publication has 5 references indexed in Scilit:
- Induction and Mechanism of Tolerance to Bovine Serum Albumin in Mice Given Total Lymphoid Irradiation (TLI)The Journal of Immunology, 1978
- Transplantation tolerance in adult rats using total lymphoid irradiation: permanent survival of skin, heart, and marrow allografts.The Journal of Experimental Medicine, 1978
- USE OF RABBIT ANTITHYMOCYTE GLOBULIN IN CARDIAC TRANSPLANTATIONTransplantation, 1976
- Successful Skin Homografts After the Administration of High Dosage X Radiation and Homologous Bone MarrowJNCI Journal of the National Cancer Institute, 1955
- The behaviour and fate of skin autografts and skin homografts in rabbits1944