A Controlled Double-Blind Evaluation of Hydroflumethiazide and Hydrochlorothiazide

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Abstract
CHLOROTHIAZIDE and hydrochlorothiazide are potent diuretic agents, but the potassium loss induced by their routine use may cause serious side effects.1 It has now been clearly established that potassium depletion is at least partly responsible for the tendency of these drugs to induce hepatic coma in susceptible patients with cirrhosis.2 Hydroflumethiazide was introduced with the hope that this modification in the structure of hydrochlorothiazide might appreciably diminish the excessive loss of potassium without compromising the drug's effectiveness as a natriuretic agent.3 The present study was designed to determine whether hydroflumethiazide produces less urinary potassium loss than hydrochlorothiazide does for an . . .