Transperitoneal Absorption of Intralipid in Rats: Total Serum Fatty Acids and Triglyceride after Absorption

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Abstract
Intralipid 20% was injected percutaneously into the peritotoneum of 58 female rats. The rats were divided into seven groups (with an additional control group of 35 rats). To measure transperitoneal absorption, we determined the serum fatty acid and triglyceride concentrations at 3-hr intervals for 24 hr, and found a considerable increase in all of the levels measured, with a maximum at about 6 hr. The serum triglyceride levels never rose above a mean value of 200 mg/100 ml. A second and smaller rise was seen after 15 hr, declining again to the initial values. The relative proportions of the different fatty acids changed, but not drastically. (Journal of Parenteral and Enteral Nutrition 10:604-608, 1986)