Primary structure and genomic organization of the histidine-rich protein of the malaria parasite Plasmodium lophurae

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Abstract
The nucleotide sequence of a complete genomic clone for the histidine-rich protein of P. lophurae was determined. The deduced amino acid sequence of the mature protein shows numerous tandemly repeated units preceded by a signal and a pro peptide. The gene is interrupted by an intron with a separate exon coding for the signal peptide. The signal peptide-encoding exon detects multiple cross-hybridizing sequences in the parasite genome.