DNA Release by Line‐1 (L1) Retrotransposon Could It Be Possible?
- 1 April 2000
- journal article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 906 (1) , 129-133
- https://doi.org/10.1111/j.1749-6632.2000.tb06602.x
Abstract
We have verified the presence of line-1 retrotransposon (L1) in plasma DNA in 15/17 brain tumor (glioma) patients and in 6/6 healthy people by applying PCR amplification of part of the L1 5' end. The same samples were separately amplified for K-ras. Results suggested that L1 sequences are circulating throughout the body. We hypothesized the participation of transposable elements such as L1 in a putative DNA release mechanism.Keywords
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