SEROTONINERGIC DYSFUNCTION IN THE 47, XYY SYNDROME

  • 1 January 1980
    • journal article
    • research article
    • Vol. 15  (6) , 917-923
Abstract
In 6 XYY patients suffering from aggressiveness and admitted by order of law into a security setting for acts of violence, the estimation of CSF amine metabolites before and after a probenecid test revealed a clear decrease in the turnover of central serotonin (5-HT) while that of dopamine (DA) was unchanged. The treatment with the 5-HT precursor, L-5-hydroxytryptophan (L-5-HTP), in 5 of the XYY patients resulted in a clinical status equivalent to that observed when the patients were previously treated by conventional neuroleptics.

This publication has 0 references indexed in Scilit: