Effects of Conditioning on Exertional Rhabdomyolysis and Serum Creatine Kinase after Severe Exercise

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Abstract
The effects of different conditioning levels on exertional rhabdomyolysis after severe exercise were studied. Well-conditioned men [15] were randomly divided into 3 conditioning groups, i.e., 0, 4 and 8 miles on alternate days for 1 mo. They were physically stressed by running 14 miles at 8 min/mile after 1 mo. of training. The effects of the different levels of conditioning on exertional rhabdomyolysis after the test run were determined by assaying serum samples for creatine kinase (CK) and myoglobin levels. Serum CK levels increased 98-294% above pre-conditioning control values after the 14-mile test run while serum myoglobin levels increased 52-405%. The most marked increases occurred in those subjects who trained < 8 miles on alternate days. These quantitative indices apparently are useful in determining the amount of conditioning necessary to prevent significant rhabdomyolysis after severe exercise.