Polymorphic DNA region adjacent to the 5' end of the human insulin gene.
- 1 September 1981
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 78 (9) , 5759-5763
- https://doi.org/10.1073/pnas.78.9.5759
Abstract
The length of a segment of DNA associated with the human insulin gene, which was localized to the short arm of chromosome 11, is heterozygous in 63% of 52 individuals analyzed. This polymorphic region is .apprx. 500 base pairs from the mucleotide encoding the 5'' end of insulin mRNA. The polymorphism may be due to an insertion or deletion of DNA sequences so that DNA fragments of different length are generated when DNA from a heterozygous individual is digested with selected restriction endonucleases.This publication has 25 references indexed in Scilit:
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