Identifying the links between obesity, insulin resistance and β‐cell function: potential role of adipocyte‐derived cytokines in the pathogenesis of type 2 diabetes
- 16 May 2002
- journal article
- review article
- Published by Wiley in European Journal of Clinical Investigation
- Vol. 32 (s3) , 24-34
- https://doi.org/10.1046/j.1365-2362.32.s3.4.x
Abstract
A combination of insulin resistance and pancreatic β‐cell dysfunction underlies most cases of type 2 diabetes. While the interplay of these two impairments is believed to be important in the developm...Keywords
This publication has 128 references indexed in Scilit:
- Insulin Resistance and Its Treatment by ThiazolidinedionesRecent Progress in Hormone Research, 2001
- PPAR-γ agonists: therapeutic role in diabetes, inflammation and cancerTrends in Pharmacological Sciences, 2000
- Altered function of insulin receptor substrate-1–deficient mouse islets and cultured β-cell linesJournal of Clinical Investigation, 1999
- Relationship of Leptin Concentration to Gender, Menopause, Age, Diabetes, and Fat Mass in African AmericansObesity Research, 1998
- Insulin Mediates Glucose-stimulated Phosphorylation of PHAS-I by Pancreatic Beta CellsPublished by Elsevier ,1998
- Treatment with the oral antidiabetic agent troglitazone improves beta cell responses to glucose in subjects with impaired glucose tolerance.Journal of Clinical Investigation, 1997
- TNF‐α inhibits glucose‐induced insulin secretion in a pancreatic β‐cell line (INS‐1)FEBS Letters, 1995
- Treatment with the Thiazolidinedione (BRL 49653) Decreases Insulin Resistance in Obese Zucker HindlimbHormone and Metabolic Research, 1995
- CYTOKINES INHIBIT FATTY ACID OXIDATION IN ISOLATED RAT HEPATOCYTESShock, 1994
- Pretranslational suppression of a glucose transporter protein causes insulin resistance in adipocytes from patients with non-insulin-dependent diabetes mellitus and obesity.Journal of Clinical Investigation, 1991