Meso-Inositol Hexanicotinate Induced Protection against Experimental Anoxia and Oedema

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Abstract
It is shown that Meso-Inositol Hexanicotinate (MIHN; Hexopal) inhibits experimentally induced oedema of the paw in rats and that mice exposed to hypoxic atmospheres (4% oxygen) show significant increase in survival time if pre-dosed with MIHN. The protection against oedema and hypoxia conferred by MIHN in experimental animals may well be related to the mode of action of the substance in man, and particularly could explain the usefulness of MIHN in the treatment of cerebral and peripheral atherosclerosis.