Susceptibility of Burned Mice to Pseudomonas aeruginosa and Protection by Vaccination

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Abstract
Mice given a moderate burn in water at 70[degree]C. were extremely susceptible to intraperitoneal injection of a dose of Pseudomonas aeruginosa that is non-lethal to normal mice. Susceptibility to pseudomonas disappeared, however, 5 days after the burn. Parenteral administration of specific vaccines, before or after the burn, affords significant protection to burned mice gien a pseudomonas challenge that is lethal to normal mice. These results suggest that thermal trauma does not block the immunologic response to bacterial antigens. For this reason specific vaccines administered after thermal trauma in man might portect burned patients from death due to bacterial septicemlas.