Cracking the Polyketide Code
Open Access
- 17 February 2004
- journal article
- primer
- Published by Public Library of Science (PLoS) in PLoS Biology
- Vol. 2 (2) , e35
- https://doi.org/10.1371/journal.pbio.0020035
Abstract
Polyketides, natural products from microorganisms, have been a main source of antibiotics. Understanding the 'programming' of the enzymes that produce these complex molecules has opened a new field of drug discovery.Keywords
This publication has 12 references indexed in Scilit:
- Engineered Biosynthesis of Regioselectively Modified Aromatic Polyketides Using Bimodular Polyketide SynthasesPLoS Biology, 2004
- Polyketide Chain Length Control by Chain Length FactorJournal of the American Chemical Society, 2003
- Mutasynthesis of Enterocin and Wailupemycin AnaloguesJournal of the American Chemical Society, 2003
- Polyketide biosynthesis beyond the type I, II and III polyketide synthase paradigmsCurrent Opinion in Chemical Biology, 2003
- The Enzymology of Combinatorial BiosynthesisCritical Reviews in Biotechnology, 2003
- A chain initiation factor common to both modular and aromatic polyketide synthasesNature, 1999
- Forty years of genetics with Streptomyces: from in vivo through in vitro to in silicoMicrobiology, 1999
- Engineered Biosynthesis of Novel PolyketidesScience, 1993
- Modular Organization of Genes Required for Complex Polyketide BiosynthesisScience, 1991
- An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraeaNature, 1990