Spermine blocks synaptic transmission mediated by Ca2+-permeable AMPA receptors

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Abstract
AMPA-GATED glutamate receptors with outward rectification (type I receptors) are almost impermeable to Ca2+, while those with strong inward rectification (type II receptors) have high Ca2+ permeability. In the present study current responses in rat hippocampal neurones mediated by type II AMPA receptors were blocked by application of spermine to the external solution (IC50 = 170 μM), but those mediated by type I AMPA receptors were not affected. Furthermore, in putative non-pyramidal neurones in rat hippocampal slices, EPSCs mediated by type II AMPA receptors were markedly reduced by 1 mM spermine, while those mediated by type I AMPA receptors were much less affected. Thus, external spermine exerts differential blocking action on the two different types of AMPA receptors.

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