MAGNITUDE AND DURATION OF THE EFFECTS OF COCAINE ON CONDITIONED AND ADJUNCTIVE BEHAVIORS IN THE CHIMPANZEE

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Abstract
Characteristic patterns of conditioned key‐pressing were maintained in the chimpanzee under a multiple 30‐response fixed‐ratio, 10‐minute fixed‐interval schedule of food presentation. Adjunctive drinking occurred with regularity during the fixed‐interval schedule and, with less frequency, during 1‐minute timeout periods that followed each food presentation; drinking seldom occurred during the fixed‐ratio schedule. Cocaine increased key pressing under the fixed‐interval schedule at doses between .1 and 3.0 mg/kg, but adjunctive drinking and key pressing under the fixed‐ratio schedule did not increase at any dose. Conditioned and adjunctive behaviors were disrupted and suppressed for different durations at 10.0 mg/kg, a dose which induced convulsive seizures within 10 minutes after intramuscular injection. A time‐course analysis showed the magnitude and duration of the effects of cocaine on key pressing under the fixed‐interval schedule and on adjunctive drinking to be dose‐related. Moreover, a given dose of cocaine had diverse effects, depending on the behavior and the time since drug administration.