Effects of Non-Viable Measles Virus on Proliferating Human Lymphocytes
- 1 January 1974
- journal article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 46 (6) , 822-833
- https://doi.org/10.1159/000231184
Abstract
We have previously found that in vitro addition of autoclaved measles virus (AMV) suppressed lymphocyte proliferation. The characteristics of this response were further explored. Proliferation induced by both PHA and PWM was depressed as was 14C-amino acid incorporation. AMV present in the medium for only the first 2–4 h of culture lead to prominent suppression. Suppressive activity was found in both dialyzable and non-dialyzable fractions of AMV. No evidence of cytotoxicity was seen by three different measurements.Keywords
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