STUDIES ON PGBX, A POLYMERIC DERIVATIVE OF PROSTAGLANDIN-B1 .1. SYNTHESIS AND PURIFICATION OF PGBX

  • 1 January 1979
    • journal article
    • research article
    • Vol. 11  (2) , 109-123
Abstract
PG[prostaglandin]Bx, a new polymeric derivative of PGB1, restored oxidative phosphorylation to degraded isolated rat liver mitochondria in vitro and reversed the effects of cardiogenic ischemia in monkeys and cerebral ischemia in rabbits. This report describes in detail the synthesis and purification of PGBx via PGB1, starting with azelaic acid. Details of the in vitro mitochondrial assay are also reported. Purified PGBx exhibiting maximal reactivation of mitochondrial phosphorylation has a mean MW of 2350. Yield of PGBx based on azelaic acid is 4% and based on PGB1 is 25%.

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