Electrochemical Decarboxylation of Hydroxyproline: A Simple Three-Step Conversion of (2S,4R)-4-Hydroxyproline to (R)-γ-Amino-β-hydroxybutanoic Acid (GABOB)
- 1 January 1986
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1986 (05) , 424-426
- https://doi.org/10.1055/s-1986-31665
Abstract
A high yield conversion on preparative scale of (2S,4R)-N-acetyl-4-hydroxyproline (1) to (R)-GABOB (4) is reported. The key step of the synthesis is the electrochemical oxidative decarboxylation of 1.Keywords
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