Inhibitory Effect of Somatostatin (SRIF) on the Release of Growth Hormone (GH) Induced in the Rat by Electrical Stimulation
- 1 February 1974
- journal article
- other
- Published by The Endocrine Society in Endocrinology
- Vol. 94 (2) , 497-502
- https://doi.org/10.1210/endo-94-2-497
Abstract
The effect of synthetic SRIF on GH release induced by hypothalamic ventromedial (VMN) and basolateral amygdaloid (BLA) electrical stimulation has been investigated in rats anesthetized by pentobarbital. SRIF administered as an intravenous infusion during stimulation (500 μg/rat) or subcutaneously 5 min before stimulation (20 μg/100 g body wt) completely blocked the 4-5-fold rise in plasma GH levels which occurred after VMN stimulation. A smaller single intravenous dose of SRIF (10 μg/100 g body wt) was effective in preventing VMN-induced release when administered at the end of stimulation but not when given immediately before stimulation. SRIF (20 μg/100 g body wt sc) was also effective in blocking BLA-induced GH release. These results indicate that SRIF is active in preventing acute GH release induced by stimulation of either brain region and suggest that the site of blockade is at the pituitary level. (Endocrinology94: 497, 1974)Keywords
This publication has 0 references indexed in Scilit: