Acetyl glyceryl ether phosphorylcholine (platelet‐activating factor) mediates heightened metabolic activity in macrophages

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Abstract
The phospholipid mediator AGEPC (acetyl glyceryl ether phosphorylcholine) was examined for its effects on guinea pig peritoneal macrophages. At a concentration of 10−9 -10−6 M, AGEPC evoked release of prostaglandin E (PGE) and thromboxane B2 (TXB2) from albumin-elicited macrophages. It also triggerd generation of O− 2 by Corynebacterium parvum-induced cells. Moreover, it caused augmented spreading of macrophages. The calmodulin antagonis W-7 attenuated AGEPC-mediated O− 2 production and cell spreading whereas prostanoid synthesis was enhanced. These novel actions of AGEPC on the major cellular component of the inflammatory process attest to its role as a potent mediator of immunoinflammatory responses.