Persistence of Group A Streptococci in Tissues of Rabbits after Infection.

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Abstract
Summary Group A streptococci persisted in the tissues of rabbits, in the absence of bacteremia, for periods up to 104 days following infection. Except in the case of suppurative arthritis such persistence was not associated with any demonstrable pathological lesion. Cortisone might have played a part in reestablishing a bacteremia in rabbits long periods after the acute infection. The significance of these findings in relation to the pathogenesis of rheumatic fever is discussed.