Palladium-catalysed cyclisation–amination of allenes-effect of base on regioselectivity of formation of allylic amines
- 1 January 1995
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 18,p. 1903-1904
- https://doi.org/10.1039/c39950001903
Abstract
The palladium catalysed cyclisation of aryl iodides onto proximal allenes occurs at the centre carbon atom of the allene forming a five- or six-membered rings and generating a π-allyl intermediate. The regiochemistry of attack of secondary amines on the π-allyl intermediate is sensitive to added inorganic base, steric effects and the nature of the adjacent heteroatom.Keywords
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