Antibody-Mediated Clearance of Alphavirus Infection From Neurons
- 8 November 1991
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 254 (5033) , 856-860
- https://doi.org/10.1126/science.1658936
Abstract
Humoral immunity is important for protection against viral infection and neutralization of extracellular virus, but clearance of virus from infected tissues is thought to be mediated solely by cellular immunity. However, in a SCID mouse model of persistent alphavirus encephalomyelitis, adoptive transfer of hyperimmune serum resulted in clearance of infectious virus and viral RNA from the nervous system, whereas adoptive transfer of sensitized T lymphocytes had no effect on viral replication. Three monoclonal antibodies to two different epitopes on the E2 envelope glycoprotein mediated viral clearance. Treatment of alphavirus-infected primary cultured rat neurons with these monoclonal antibodies to E2 resulted in decreased viral protein synthesis, followed by gradual termination of mature infectious virion production. Thus, antibody can mediate clearance of alphavirus infection from neurons by restricting viral gene expression.Keywords
This publication has 21 references indexed in Scilit:
- The myelin-associated glycoprotein is enriched in multivesicular bodies and periaxonal membranes of actively myelinating oligodendrocytes.The Journal of cell biology, 1989
- Antibody inhibits defined stages in the pathogenesis of reovirus serotype 3 infection of the central nervous system.The Journal of Experimental Medicine, 1989
- Differential expression and regulation of major histocompatibility complex (MHC) products in neural and glial cells of the human fetal brainJournal of Neuroimmunology, 1988
- Chronic Enteroviral Meningoencephalitis in Agammaglobulinemic PatientsClinical Infectious Diseases, 1987
- Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiencyCell, 1986
- A severe combined immunodeficiency mutation in the mouseNature, 1983
- Non-neutralizing monoclonal antibodies can prevent lethal alphavirus encephalitisNature, 1982
- Role of the Immune Response in Age-Dependent Resistance of Mice to Encephalitis Due to Sindbis VirusThe Journal of Infectious Diseases, 1976
- Cellular immune response to viral infection: In vitro studies of lymphocytes from mice infected with Sindbis virusCellular Immunology, 1973
- Age-dependent Resistance to Viral Encephalitis: Studies of Infections Due to Sindbis Virus in MiceThe Journal of Infectious Diseases, 1972