A Two-step Synthesis of the Anti-cancer Drug (R,S)-Bicalutamide
- 14 May 2002
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 2002 (07) , 850-852
- https://doi.org/10.1055/s-2002-28508
Abstract
A short, efficient synthesis of the non-steroidal antiandrogen (R,S)-bicalutamide is presented. This new route generates bicalutamide in only two steps with an overall yield of 73%. The key step is a 1,2 addition of a methyl sulfone to a keto-amide.Keywords
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