Man-made antibodies
- 1 January 1991
- journal article
- review article
- Published by Springer Nature in Nature
- Vol. 349 (6307) , 293-299
- https://doi.org/10.1038/349293a0
Abstract
Monoclonal antibodies can now be genetically engineered and endowed with new properties. In the future, gene technology could enable antigen-binding fragments to be made by exploiting repertoires of variable domain genes derived from immunized animals and expressed in bacteria. How readily can this approach be extended to production of 'in vitro' repertoires of variable domain genes, and obviate the immunization of animals?Keywords
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