NEW LOOK AT TYPE-I IMMEDIATE HYPERSENSITIVITY IMMUNE-REACTIONS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 36  (5) , 337-341
Abstract
The pathogenesis of type I disorders, particularly allergic asthma and urticaria, requires a critical review in the light of recent findings which indicate a 2nd pathway for the release of granulocyte mediators. The isolation of enzyme activity of some of these released mediators establishes a direct link between the immunological system and bradykinin, as well as a system of self modulation of kinin activity. These findings enable a broader understanding of the asthmatic process and lay the foundation for integrating extrinsic and intrinsic asthma.

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