Pulmonary Adenomatosis Induced in DBA/2 Mice by Oral Administration of Dibenz[a,h]-anthracene

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Abstract
Fourteen male and 13 female DBA/2 mice, given an aqueous olive-oil emulsion of dihenz[a, h]anthracene in place of drinking water for 200 days or longer, developed pulmonary adenomatosis. The lesion was found also in 1 control mouse given the olive-oil emulsion without dihenz[a, h]anthracene. Mice that drank the emulsion containing dibenz[a, h]anthracene developed alveologenic carcinoma, tumors of the mammary gland, precancerous lesions of the small intestine, and hemangioendotheliomas involving the pancreas, mesentery, and abdominal lymph nodes. These and other lesions induced by the treatment, as well as spontaneous lesions to which DBA/2 mice are subject, are described and discussed. A comparison is made with an experiment performed 13 years previously in which strain DBA/2 mice were also given an aqueous olive-oil emulsion containing dibenz[a, h]anthracene in place of drinking water but at a lower level of intake of the carcinogenic hydrocarbon. Fewer lesions of pulmonary adenomatosis but more neoplastic lesions of the small intestine developed in the earlier experiment.