Model Studies in Molecular Recognition
- 20 March 1987
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 235 (4795) , 1478-1484
- https://doi.org/10.1126/science.3823899
Abstract
Recognition at the molecular level is a fundamental characteristic of biochemical systems. Recent models developed in bioorganic chemistry have revealed the importance of complementarity in size, shape, and functional groups in molecular recognition. Structures that feature a cleft are particularly effective in regard to complementarity since functional groups attached to the interior of the cleft converge on substrates held inside. The molecular clefts offer the advantage of efficient construction; their surfaces can be tailored for specific applications. This article describes their use for recognition of acids, bases, amino acids, metal ions, and neutral substrates. Their ability to provide microenvironments complementary to asymmetric molecules and their future promise are discussed.Keywords
This publication has 57 references indexed in Scilit:
- Intermolecular proton[proton] nuclear Overhauser effects in diastereomeric complexes: support for a chromatographically derived chiral recognition modelJournal of the American Chemical Society, 1986
- Binding forces and catalysis. The use of bipyridyl-metal chelation to enhance reaction ratesJournal of the American Chemical Society, 1985
- Convergent functional groups: synthetic and structural studiesJournal of the American Chemical Society, 1985
- Artificial allosteric system. 2. Cooperative 1-methylimidazole binding to an artificial allosteric system, zinc-gable porphyrin-dipyridylmethane complexJournal of the American Chemical Society, 1985
- Epoxidation of olefins by cytochrome P-450 model compounds: kinetics and stereochemistry of oxygen atom transfer and origin of shape selectivityJournal of the American Chemical Society, 1985
- Artificial transaminase carrying a synthetic macrocyclic binding groupJournal of the American Chemical Society, 1983
- A carbonate receptor model by macromonocyclic polyamines and its physiological implicationsJournal of the American Chemical Society, 1982
- Hydrogen-bond structure in carbohydrate crystalsAccounts of Chemical Research, 1978
- Interaction and Association of Bases and Nucleosides in Aqueous Solutions. IV. Proton Magnetic Resonance Studies of the Association of Pyrimidine Nucleosides and Their Interactions with Purine1bJournal of the American Chemical Society, 1965
- Synthese des 9.10‐Cyclopenteno‐phenanthrens und einiger MethylhomologenEuropean Journal of Inorganic Chemistry, 1955