Conformation-activity relationship study of 5-HT3 receptor antagonists and a definition of a model for this receptor site
- 1 June 1990
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 33 (6) , 1594-1600
- https://doi.org/10.1021/jm00168a011
Abstract
A conformation-activity relationship study of 5-HT3 receptor antagonists was used to define a pharmacophore and receptor map to qualitatively account for their activity. The design and synthesis of specific keto-amino-indole derivatives that are potent 5-HT3 receptor antagonists gave some support to the model.This publication has 0 references indexed in Scilit: