Production of Urinary Bladder Carcinomas in Male Hamsters by N-[4-(5-Nitro-2-furyl)-2-thiazolyl]formamide, N-[4-(5-Nitro-2-furyl)-2-thiazolyl]-acetamide, or Formic Acid 2-[4-(5-Nitro-2-furyl)-2-thiazolyi]hydrazide2
- 1 September 1973
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 51 (3) , 941-949
- https://doi.org/10.1093/jnci/51.3.941
Abstract
N-[4-(5-Nitro-2-furyl)-2-thiazolyl]formamide (FANFT), N-[4-(5-nitro-2-furyl)-2-thiazolyl]-acetamide (NFTA), or formic acid 2-[4-(5-nitro-2-furyl)-2-thiazolyl]hydrazide (FNT), potent carcinogens for the rat, mouse, and dog, were fed at 0.1% of the diet to male weanling Syrian golden hamsters for 48 weeks, followed by control diet for an additional 22 weeks. The incidences of tumors were: FANFT—23 of 24 hamsters with urinary bladder transitional carcinomas, 5 of 24 with forestomach squamouscell papillomas, and 1 of 24 with an adrenal adenoma,- NFTA—16 of 24 hamsters with urinary bladder transitional cell carcinomas, 1 of 24 with an adrenal adenoma, and 1 of 24 with an adrenal adenocarci-noma; and FNT—9 of 24 hamsters with urinary bladder transitional cell carcinomas, 13 of 24 with fore-stomach squamous cell papillomas, 6 of 24 with adrenal adenomas, and 1 of 24 with a renal transitional cell carcinoma. Only 1 adrenal adenoma was found in the untreated hamsters. These data demonstrate that hamsters are as susceptible as other species to the carcinogenicity of 5-nitrofurans.Keywords
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