The cutaneous side-effects of hydroxyurea
- 1 August 2000
- journal article
- case report
- Published by Wiley in Clinical and Laboratory Haematology
- Vol. 22 (4) , 229-232
- https://doi.org/10.1046/j.1365-2257.2000.00311.x
Abstract
The cutaneous side‐effects of long‐term hydroxyurea therapy are not widely known and only rarely reported. We report on a patient who developed widespread skin changes, including the recently recognized hydroxyurea dermopathy, during long‐term treatment with hydroxyurea for polycythaemia rubra vera. The time course of the clinical changes suggests that they result from direct toxicity of hydroxyurea on the basal layer of the epidermis and mucosal surfaces. We aim to increase clinical awareness of this problem.Keywords
This publication has 9 references indexed in Scilit:
- Leg ulcers associated with long-term hydroxyurea therapyJournal of the American Academy of Dermatology, 1998
- Hydroxyurea-induced dermopathy: A unique lichenoid eruption complicating long-term therapy with hydroxyureaJournal of the American Academy of Dermatology, 1998
- Hydroxyurea-Induced Leg Ulceration in 14 PatientsAnnals of Internal Medicine, 1998
- Hydroxyurea dermopathy: A unique lichenoid eruption complicating long-term therapy with hydroxyureaJournal of the American Academy of Dermatology, 1997
- Hydroxyurea-induced dermatomyositis-like eruptionBritish Journal of Dermatology, 1995
- CUTANEOUS MANIFESTATIONS OF LONG‐TERM HYDROXYUREA THERAPYAustralasian Journal of Dermatology, 1994
- Multiple skin tumors in long‐term treatment with hydroxyureaEuropean Journal of Haematology, 1992
- Effects of hydroxyurea therapy on normal skin: a case reportClinical and Experimental Dermatology, 1980
- EFFECTS OF ANTIPSORIASIS DRUGS AND METABOLIC INHIBITORS ON THE GROWTH OF EPIDERMAL CELLS IN CULTUREJournal of Investigative Dermatology, 1978