Recognition of the superscan in prostatic bone scintigraphy

Abstract
Widespread bone metastases occasionally give rise to a uniform distribution of 99mTc methylene diphosphonate resulting in a superficially normal appearance on the bone scan. The scans are recognizable by the high ratio of bone to soft tissue activity and the absence of focal lesions in the axial skeleton. There are usually no renal images. These superscans are occasionally misinterpreted as normal. An index of image quantitation related to the ratio of bone to soft tissue uptake is capable of clearly distinguishing these patients from patients in other categories. The condition is presumably more frequently associated with prostatic carcinoma than other etiologies.