IGG HEAVY-CHAIN ALLOTYPE (GM), A GENETIC-MARKER FOR HUMAN-CHROMOSOME 14Q32, AND HEMATOPOIETIC MALIGNANCIES

  • 1 January 1984
    • journal article
    • research article
    • Vol. 56  (3) , 628-636
Abstract
IgG H chain constant region allotypes, Gm, the genetic marker of human chromosome 14q32, are markers for susceptibility to certain diseases. Gm allotypes were tested in 365 patients with various types of hematological malignancies, 528 healthy controls and 35 healthy HTLV [human T cell leukemia-lymphoma virus] carriers. The frequency of specific Gm phenotypes was significantly increased in patients with adult onset null-ALL [acute lymphocytic leukemia], AML [acute myelocytic leukemia], AMoL [acute monocytic leukemia] and CML [chronic myelocytic leukemia] in blastic crisis. Among these diseases, the frequency of Gm1,2,21 haplotype was significantly increased with adult onset null-ALL, AML and AMoL.