Abstract
An approximation to the modified profile likelihood function is proposed. This approximation is invariant under interest-respecting reparameterisations, it agrees with the modified profile likelihood function to order O(n−1) in the moderate-deviation sense and to order O(n−½) in the large-deviation sense, and it is stable in the sense of conditional inference. For the case of a curved exponential family model this approximation agrees with the one proposed by Barndorff-Nielsen (1995). A general expression for the approximate modified profile likelihood function is given for nonlinear regression models and for generalised linear models with known dispersion parameter.

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