Co‐expression of the proto‐oncogene FOS (c‐fos) and an embryonic interferon (ovine trophoblastin) by sheep conceptuses during implantation

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Abstract
Summary— Expression of the c‐fos proto‐oncogene by ovine conceptuses was analyzed by Northern and slot blots and indirect immunohistofluorescence in relation to the expression of the embryonic interferon‐α (oTP) during implantation. c‐fos was expressed initially in the trophoblast, and then in the allantois, when this tissue began to develop (day 17). In the embryonic tissues, the c‐fos proto‐oncogene was weakly expressed up to day 22 and increased thereafter. In the trophoblast, the expression of c‐fos proto‐oncogene was transient, occurring when the oTP gene was transcribed at a maximal level at the beginning of implantation (days 14–15), and decreased thereafter, following the pattern of oTP gene expression. This decline is due essentially to the arrest of c‐fos and oTP gene expression by the trophoblastic cells which established cellular contacts with the uterine epithelium during the implantation process.

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