Infinite allele model with varying mutation rate.
- 1 November 1976
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 73 (11) , 4164-4168
- https://doi.org/10.1073/pnas.73.11.4164
Abstract
The variation in mutation rate among protein loci follows the .gamma.-distribution. Taking into account this variation, formulae are developed for the distribution of allele frequencies, mean and variance of heterozygosity, expected number of alleles, proportion of polymorphic loci, and genetic distance. These formulae should be more appropriate for the analysis of gene frequency data for protein loci than equivalent formulae with constant mutation rate.This publication has 12 references indexed in Scilit:
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