Thrombotic Disorders with Increased Levels of Antiplasmin and Antiplasminogen

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Abstract
DESPITE recent advances in the understanding of hemostasis the cause of many thrombotic disorders has not been established. Thrombosis is probably the common expression of diverse etiologies, some originating in the vascular wall, others in the intrinsic coagulation mechanism and still others in extravascular disturbances. Among these possibilities an increased inhibition of normal clot lysis has been described as a cause of abnormal thrombi.1 2 3 4 Although a number of such inhibitors have been reported,5 6 7 8 to date they have been thought significant chiefly as factors that may complicate fibrinolytic therapy. Only a few reports have noted increased levels of such inhibitors in . . .