Role of the Central Circulation in Regulation of Cutaneous Gas Exchange

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Abstract
SYNOPSIS. Although primarily limited by the rate of diffusion of oxygen and carbon dioxide across the integument, cutaneous gas exchange is also affected by adjustments in the absolute flow of blood to the skin, the pattern of distribution of blood within the cutaneous vascular bed, and the effects of central vascular shunting on gas partial pressures of arterial blood perfusing the skin. The interplay of these various factors, particularly in animals with heterogeneous arterial supply to the skin and/or with highly variable intracardiac shunts, potentially is complex, only poorly understood, and worthy of considerable future experimentation.

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